Infantile Spastic Paraplegia

Hereditary spastic paraplegia.

Hereditary spastic paraplegia (HSP) or Strümpell-Lorrain syndrome is a heterogeneous group of inherited disorders, with prevalence ranged from 4.3 to 9.6 cases per 100,000 population. A common feature of these disorders is the slowly progressive and often severe spasticity, noticeably especially in the low limbs. Conventionally, HSP is divided into two clinical groups, uncomplicated (pure spast...

Hereditary Spastic Paraplegia.

111 families, and Paskind and Stone (1933) also summarized the literature with accounts of another 36 reports from 40 families. Since then about 50 further reports have appeared, covering some 60 families, bringing the total so far to 176 reports of 215 families. Of these the majority have originated in Germany or elsewhere in Europe, but with a substantial number from the Americas. In Britain,...

Subdural Hematoma and Spastic Paraplegia

This is a case of progressive lower limb weakness in a 72-year-old man secondary to chronic bilateral subdural hematoma. This patient presented with a 3 week history of progressive difficulty in walking, with upper motor neuron signs but no sensory deficit. He had no significant risk factors for chronic subdural hematoma. Literature search revealed only one similar documented case of painless b...

Spastic Paraplegia in Middle Age.

SPG3A gene polymorphisms in hereditary spastic paraplegia

Objective: This study aimed to analyze the hereditary spastic paraplegia (HSP)/spastic paraplegia 3A (SpG3A) genomic structure as well as the polymorphisms in SPG3G genomic structure by comparing with the normal subjects. Methods: A total of 66 sporadic cases with HSP were collected from April 2014 to September 2016. Genomic DNA extraction was performed, and all coding exons and junction region...